Efeito antioxidante da diosmina: revisão integrativa

Amanda Francielle Santos, Rafaela Ribeiro Machado, José Marden Mendes Neto, Míriam Geisa Virgens Menezes, Gilmara Beatriz Andrade da Silva, Sandra Lauton Santos

Resumo


O estresse oxidativo está relacionado ao desenvolvimento de muitas enfermidades e atualmente tem-se utilizado a Diosmina visando reduzi-lo. O objetivo deste estudo é identificar através da literatura o efeito antioxidante da Diosmina. Trata-se de um estudo descritivo bibliográfico de revisão integrativa, realizada a partir artigos que abordassem o tema pesquisado publicados entre 2013 a 2017 oriundos das bases de dados eletrônicas PubMed e Bireme. Foram analisados 9 artigos. Os estudos avaliados evidenciam que com a utilização da Diosmina há uma elevação da quantidade no organismo de enzimas que combatem o estresse oxidativo como, catalase e outras. E também que ocorreu a redução do Malondialdeído. Conclui-se com esse estudo que a Diosmina contribui para o combate das lesões desencadeadas pelo desequilíbio no status redox que estimula o aumento de antioxidantes enzimáticos e inibe a formação de malondialdeído, assim colaborando para a diminuição de danos aos tecidos.


Palavras-chave


antioxidante; Diosmina; estresse oxidativo.

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Referências


Jacob KD, NorenHooten N, Trzeciak AR, Evans MK. Markers of oxidant stress that are clinically relevant in aging and age-related disease. Mech Ageing Dev. 2013;134(3-4):139-57. http://dx.doi.org/10.1016/j.mad.2013.02.008

Gasparovic AC, Jaganjac M, Mihaljevic B, Sunjic SB, Zarkovic N. Assays for the measurement of lipid peroxidation. Methods Mol Biol. 2013;965:283-96. http://dx.doi.org/10.1007/978-1-62703-239-119

McCord JM. The evolution of free radical and oxidative stress. Am J Med. 2000;108(8):652-9. https://dx.doi.org/10.1016/S0002-9343(00)00412-5

Sterba M, Popelová O, Vávrová A, Jirkovský E, Kovaríková P, Gerš V, et al. Oxidative stress, redox signaling, and metal chelation in anthracyclinecardiotoxicity and pharmacological cardioprotection. Antioxid Redox Signal. 2013;18(8):899-929. https://dx.doi.org/10.1089/ars.2012.4795

Nordberg J, Arner ESJ. Reactive oxygen species, antioxidant and the mammalian thioredoxin system. Free Rad Biol and Med. 2001;31(11):1287-312. https://dx.doi.org/10.1016/S0891-5849(01)00724-9

Barbosa KBF, Costa NMB, Alfenas RCG, Paula SO, Minim VPR, Bressan J. Estresse oxidativo: conceito, implicações e fatores modulatórios. Rev Nutr. 2010;23(4):629-43. http://dx.doi.org/10.1590/S1415-52732010000400013

McCord, JM.The evolution of free radicals and oxidative stress. Am J Med. 2000;108(8):652-9. http://dx.doi.org/10.1016/S0002-9343(00)00412-5

Betteridge, DJ. What is oxidative stress? Metabolism. 2000;49(2 Suppl 1):3-8. http://dx.doi.org/10.1016/S0026-0495(00)80077-3

Halliwell B. Oxidants and human disease: some new concepts. FASEB J. 1987;1(5):358-64. https://dx.doi.org/10.1096/fasebj.1.5.2824268

Barreiros ALBS, David JM, David JP. Estresse oxidativo: relação entre geração de espécies reativas e defesa do organismo. Quím Nova. 2006;29(1):113-23. http://dx.doi.org/10.1590/S0100-40422006000100021

Cook NC, Sammans S. Flavonoids- Chemistry, metabolism, cardioprotective effects, and dietary sources. J Nutr Biochem. 1996;7:66-76. https://dx.doi.org/10.1016/S0955-2863(95)00168-9

Tahir M, Rehman MU, Lateef A, Khan AQ, Khan R, Qamar W, et al. Diosmin abrogate schemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model. Toxicol Lett. 2013;220(3):205-18. http://dx.doi.org/10.1016/j.toxlet.2013.04.004

Tamamoto LC1, Schmidt SJ, Lee SY. Sensory profile of a model energy drink with varying levels of functional ingredients-caffeine, ginseng, and taurine. J Food Sci. 2010;75(6):S271-8. https://dx.doi.org/10.1111/j.1750-3841.2010.01655.x

Craig WJ. Health promoting properties of common herbs. Am J Clin Nutr. 1999;70(Suppl.3):491s-9. https://dx.doi.org/10.1111/10.1093/ajcn/70.3.491s

Silambarasan T, Raja B. Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats. Eur J Pharmacol. 2012;679(1-3):81-9. dx.https://dx.doi.org/10.1016/j.ejphar.2011.12.040

Ahmed S, Mundhe N, Borgohain M, Chowdhury L, Kwatra M, Bolshette N, et al. Diosmin modulates the NF-kB signal transduction pathways and downregulation of various oxidative stress markers in alloxan induced diabetic nephropathy. Inflammation. 2016;39(5):1783-97. http://dx.doi.org/10.1007/s10753-016-0413-4

Tanrikulu Y, Sahin M, Kismet K, Kilicoglu SS, Devrim E, Tanrikulu CS, et al. The protective effect of diosmin on hepatic ischemia reperfusion injury: an experimental study. Bosn J Basic Med Sci. 2013;13(4):218-24. http://dx.doi.org/10.17305/bjbms.2013.2305

Queenthy SS, John B. Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats. Eur J Pharmacol. 2013;718(1-3):213-8. http://dx.doi.org/10.1016/j.ejphar.2013.08.031

Rehman MU, Tahir M, Quaiyoom Khan A, Khan R, Lateef A, Hamiza OO, et al. Diosmin protects against trichloroethyleneinduced renal injury in Wistar rats: plausible role of p53, Bax and caspases. Br J Nutr. 2013;110(4):699-710. dx.https://dx.doi.org/10.1017/S0007114512005752

Senthamizhselvan, Manivannan J, Silambarasan T, Raja B. Diosmin pretreatment improves cardiac function and suppresses oxidative stress in rat heart after ischemia/reperfusion. Eur J Pharmacol. 2014;736:131-7. http://dx.doi.org/10.1016/j.ejphar.2014.04.026

Arab HH, Salama SA, Omar HA, Arafael-SA, Maghrabi IA. Diosmin protects against ethanol-induced gastric injury in rats: novel antiulcer actions. PloS One. 2015;10(3):e0122417. https://dx.doi.org/10.1371/journal.pone.0122417

Schlottfeldt FS, Fernandes SM, Martins DM, Cordeiro P, Fonseca CD, Watanabe M, et al. Prevenção da nefrotoxicidade da anfotericina B por meio do uso de fitomedicamentos. Rev Esc Enferm USP. 2015;49(esp)74-9. http://dx.doi.org/10.1590/S0080-623420150000700011

Hasan HF, Abdel-Rafei MK, Galal SM. Diosmin attenuates radiation-induced hepatic fibrosis by boosting PPAR-γ expression and hampering miR-17-5p-activated canonical Wnt-β-catenin signaling. Biochem Cell Biol. 2017;95(3):400-14. https://dx.doi.org/10.1139/bcb-2016-0142

Bondeva T, Wolf G. Reactive oxygen species in diabetic nephropathy: friend or foe? Nephrol Dial Transplant. 2014;29(11):1998-2003. https://dx.doi.org/10.1093/ndt/gfu037

Hasanoglu E, Altan N, Sindel S, Ongun CO, Bali M, Altintas E. The relation ship between erythrocyte superoxide dismutase activity and plasma levelsof some trace elements (AL, CU, ZN) of dialysis patients. Gen Pharmacol. 1994;25(1):107-10. https://dx.doi.org/10.1016/0306-3623(94)90018-3

Richard MJ,ArnaudJ,Jurkovitz C, Hachache T, Meftahi H, Laporte F, et al. Trace elements and lipid peroxidation abnormalities in patients with chronic renal failure. Nephron 1991;57:10-15. https://dx.doi.org/10.1159/000186208

Abdalla DSP. Antioxidantes. Conceitos básicos e perspectivas terapêuticas. ARS Cvrandi. 1993;26:141-64.

Halliwell B, Gutteridge JM, Cross CE. Free radicals, antioxidants, and human disease: where are we now? J Lab Clin Med. 1992;119(6):598-620.

Kim MJ, Lim Y. Protective effect of short-term genistein supplementation on the early stage in diabetes-induced renal damage. Mediators Inflamm. 2013;2013:510212. https://dx.doi.org/10.1155/2013/510212




DOI: https://doi.org/10.7322/abcshs.v43i3.1024

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Direitos autorais 2018 Amanda Francielle Santos, Rafaela Ribeiro Machado, Míriam Geisa Virgens Menezes, José Marden Mendes Neto, Sandra Lauton Santos, Gilmara Beatriz Andrade da Silva

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Esta obra está licenciada sob uma licença Creative Commons Atribuição 4.0 Internacional.