Preterm premature rupture of membranes: management between 28 and 34 weeks of pregnancy

Main Article Content

Isabela Cason
Chayene Aguiar Rocha
Rosely Erlach Goldman


Introduction: Premature rupture of membranes remains a challenge for professionals due to the high rates of maternal and neonatal morbidity and mortality, mainly related to complications resulting from prematurity. Objective: To analyze the scientific production about premature rupture of membranes in pregnancies above 28 weeks and below 34 weeks. Methods: Integrative literature review carried out in the Lilacs, SciELO, Medline and Cochrane Library databases, between 2014 and 2018, in Portuguese, English and Spanish, including original articles, available in full online, with free access, that addressed the study theme, using the keywords "premature rupture of ovular membranes", "premature labor" and "pregnancy complications" combined using the Boolean operators "AND" and "OR". Results: Fourteen studies were included. It was possible to highlight the main recommendations regarding preterm premature rupture of membranes, divided into six categories for discussion, namely: indications for expectant management and delivery induction, prophylactic antibiotic therapy, prenatal corticosteroids, use of tocolytics, recommendations regarding the use of magnesium sulfate and amniocentesis. Conclusion: It was identified that expectant management is the ideal approach, with constant monitoring of the pregnant woman and the fetus, in addition to the administration of prophylactic antibiotics and prenatal corticosteroids, in the face of premature rupture of membranes in pregnancies between 28 and 34 weeks in order to provide the best maternal and perinatal results, guiding health professionals to evidence-based practice.


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Cason, I., Rocha, C. A., & Goldman, R. E. (2021). Preterm premature rupture of membranes: management between 28 and 34 weeks of pregnancy. ABCS Health Sciences, 46, e021309.
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Author Biographies

Isabela Cason, Escola Paulista de Enfermagem, Universidade Federal de São Paulo (UNIFESP) – São Paulo (SP), Brazil

Enfermeira graduada pela Universidade Federal de São Paulo – UNIFESP. São Paulo – Brasil.

Chayene Aguiar Rocha, Escola Paulista de Enfermagem, Universidade Federal de São Paulo (UNIFESP) – São Paulo (SP), Brazil

Enfermeira graduada pela Universidade Federal de São Paulo – UNIFESP. São Paulo – Brasil.

Rosely Erlach Goldman, Departamento de Enfermagem na Saúde da Mulher, Escola Paulista de Enfermagem, UNIFESP – São Paulo (SP), Brazil

Enfermeira Obstetra, Pós-Doutorado pela Escola Paulista de Enfermagem da Universidade Federal de São Paulo e Professora associada da Escola Paulista de Enfermagem, Universidade Federal de São Paulo, São Paulo – Brasil.


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