Risk assessment and nutritional prognosis of clinical outcome in critically ill patients

Main Article Content

Janderson Pinheiro de Souza
Karine Marques Vermeulen-Serpa
Márcia Marília Gomes Dantas Lopes
Sancha Helena de Lima Vale
Lucia Leite-Lais

Abstract

Introduction: Nutrition assessment of critically ill patients is challenging but it should be part of the clinical nutrition routine in the hospital setting. Objective: To assess the nutritional risk and prognosis of patients admitted to the intensive care unit (ICU) of a University Hospital in Natal, Brazil. Methods: Cross-sectional study developed with adult and elderly patients between February 2017 and February 2020. The nutritional risk was detected by the modified Nutrition Risk in Critically Ill score (mNUTRIC-score). The nutritional prognosis was assessed using the phase angle (PA), calculated from the resistance and reactance values provided by bioimpedance. Mann-Whitney test was used to verify the association of mNUTRIC-score and PA with the outcome (hospital discharge or death). Spearman's correlation coefficient was used to verify the correlation between mNUTRIC-score and PA. Results: A total of 55 patients were included in this study. The average value of the NUTRIC score and PA was 3.13 ± 2.35 and 4.19 ± 1.21, respectively. Most patients had low nutritional risk. Among them, 81.8% were discharged and 18.2% died. Both mNUTRIC-score (p≤0.0001) and PA (p=0.04) were associated with the clinical outcome. These two parameters were negatively correlated (r=-0.3804; p=0.0059). Conclusion: Most of the patients had a low nutritional risk determined by the mNUTRIC-score. Those with high nutritional risk had a worse outcome (death). A negative correlation was observed between the mNUTRIC score and the PA, showing that the higher the nutritional risk, the worse prognosis was found in critically ill patients.

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How to Cite
Souza, J. P. de, Vermeulen-Serpa, K. M., Lopes, M. M. G. D., Vale, S. H. de L., & Leite-Lais, L. (2023). Risk assessment and nutritional prognosis of clinical outcome in critically ill patients. ABCS Health Sciences, 48, e023233. https://doi.org/10.7322/abcshs.2021164.1875
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Original Articles
Author Biographies

Janderson Pinheiro de Souza, Curso de Nutrição, Universidade Federal do Rio Grande do Norte (UFRN) – Natal (RN), Brazil

Nutricionista pela Universidade Federal do Rio Grande do Norte (UFRN), Natal-RN, Brasil

Karine Marques Vermeulen-Serpa, Programa de Mestrado em Ciências da Saúde, Universidade Federal do Rio Grande do Norte (UFRN) – Natal (RN), Brazil

Nutritionist, Master Science in Health Science, Federal University of Rio Grande do Norte, Natal-RN, Brazil 

Márcia Marília Gomes Dantas Lopes, Programa de Doutorado em Ciências da Saúde, Universidade Federal do Rio Grande do Norte (UFRN) – Natal (RN), Brazil /Departamento de Nutrição, Universidade Federal do Rio Grande do Norte (UFRN) – Natal (RN), Brazil

Nutritionist, Ph.D. in Health Science, Professor of Department of Nutrition, Federal University of Rio Grande do Norte, Natal-RN, Brazil

Sancha Helena de Lima Vale, Programa de Doutorado em Ciências da Saúde, Universidade Federal do Rio Grande do Norte (UFRN) – Natal (RN), Brazil /Departamento de Nutrição, Universidade Federal do Rio Grande do Norte (UFRN) – Natal (RN), Brazil

Nutritionist, Ph.D. in Health Science, Professor at the Department of Nutrition, Federal University of Rio Grande do Norte, Natal-RN, Brazil

References

Singer P, Blaser AR, Berger MM, Alhazzani W, Calder PC, Casaer MP, et al. ESPEN guideline on clinical nutrition in the intensive care unit. Clin Nutr. 2019;38(1):48-79. https://doi.org/10.1016/j.clnu.2018.08.037

Ribeiro LMK, Oliveira Filho RS, Caruso L, Lima PA, Damasceno NRT, Soriano FG. Adequação dos balanços energético e proteico na nutrição por via enteral em terapia intensiva: quais são os fatores limitantes? Rev Bras Ter Intensiva. 2014;26(2):155-62. https://doi.org/10.5935/0103-507X.20140023

Osooli F, Abbas S, Farsaei S, Adibi P. Identifying Critically Ill Patients at Risk of Malnutrition and Underfeeding: A Prospective Study at an Academic Hospital. Adv Pharm Bull. 2019;9(2):314-320. https://doi.org/10.15171/apb.2019.037

Hejazi N, Mazloom Z, Zand F, Rezaianzadeh A, Amini A. Nutritional Assessment in Critically Ill Patients. Iran J Med Sci. 2016;41(3):171-9.

Heyland DK, Dhaliwal R, Jiang X, Day AG. Identifying critically ill patients who benefit the most from nutrition therapy: the development and initial validation of a novel risk assessment tool. Crit Care. 2011;15(6):R268. https://doi.org/10.1186/cc10546

Rahman A, Hasan RM, Agarwala R, Martin C, Day AG, Heyland DK. Identifying critically ill patients who will benefit most from nutritional therapy: Further validation of the "modified NUTRIC" nutritional risk assessment tool. Clin Nutr. 2016;35(1):158-62. https://doi.org/10.1016/j.clnu.2015.01.015

Jeong DH, Hong SB, Lim CM, Koh Y, Seo J, Kim Y, et al. Comparison of Accuracy of NUTRIC and Modified NUTRIC Scores in Predicting 28-Day Mortality in Patients with Sepsis: A Single Center Retrospective Study. Nutrients. 2018;10(7):911. https://doi.org/10.3390/nu10070911

Lukaski HC, Kyle UG, Kondrup, J. Assessment of adult malnutrition and prognosis with bioelectrical impedance analysis. Curr Opin Clin Nutr Metab Care. 2017;20(5):330-9. https://doi.org/10.1097/MCO.0000000000000387

Norman K, Stobãus N, Pirlich M, Bosy-Westphal A. Bioelectrical phase angle and impedance vector analysis – Clinical relevance and applicability of impedance parameters. Clin Nutrit. 2012;31(6):854-61. https://doi.org/10.1016/j.clnu.2012.05.008

Silva TK, Berbigier MC, Rubin BA, Moraes RB, Souza GC, Perry IDS. Phase angle as a prognostic marker in patients with critical illness. Nutr Clin Pract. 2015;30(2):261-5. https://doi.org/10.1177/0884533615572150

Lee SY, Lee YJ, Yang JH, Kim CM, Choi WS. The Association between Phase Angle of Bioelectrical Impedance Analysis and Survival Time in Advanced Cancer Patients: Preliminary Study. Korean J Fam Med. 2014;35(5):251-6. https://doi.org/10.4082/kjfm.2014.35.5.251

Lukaski HC, Bolonchuk WW, Hall CB, Siders WA. Validation of tetrapolar bioelectrical impedance method to assess human body composition. J Appl Physiol. 1986;60(4):1327-32. https://doi.org/10.1152/jappl.1986.60.4.1327

Mendes R, Policarpo S, Fortuna P, Alves M, Virella D, Heyland DK, et al. Nutritional risk assessment and cultural validation of the modified NUTRIC score in critically ill patients multicenter prospective cohort study. J Crit Care. 2017; 37:45-9. https://doi.org/10.1016/j.jcrc.2016.08.001

Marchett J, Reis AM, Santos AF, Franzosi OS, Luft VC, Steemburgo T. O elevado risco nutricional está associado a desfechos desfavoráveis em pacientes internados na unidade de terapia intensiva. Rev Bras Ter Intensiva. 2019;31(3):326-32. https://doi.org/10.5935/0103-507X.20190041

Özbilgin Ş, Hancı V, Ömür D, Özbilgin M, Tosun M, Yurtlu S, et al. Morbidity and mortality predictivity of nutritional assessment tools in the postoperative care unit. Medicine. 2016;95(40):5038. https://doi.org/10.1097/MD.0000000000005038

Aragão NLP, Mourão ACSM, Beltrão BA, Araújo VN, Viana J AB, Peixoto Junior AA. Avaliação de uma ferramenta nutricional como preditor de prognóstico do paciente gravemente enfermo. Rev Med UFC. 2019;59(1):34-8. https://doi.org/10.20513/2447-6595.2019v59n1p34-38

McClave SA, Taylor BE, Martindale RG, Warren MM, Johnson DR, Braunschweig C, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically Ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN J Parenter Enteral Nutr. 2016;40(2):159-211. https://doi.org/10.1177/0148607115621863

Wilhelm-Leen ER, Hall YN, Horwitz RI, Chertow GM. Phase angle, frailty, and mortality in older adults. J Gen Intern Med. 2014;29(1):147-54. https://doi.org/10.1007/s11606-013-2585-z

Delgado C, Doyle JW, Johansen KL. Association of frailty with body composition among patients on hemodialysis. J Ren Nutr. 2013;23(5):356-62. https://doi.org/10.1053/j.jrn.2013.02.010

Pinheiro M, Mancio J, Conceição G, Ferreira W, Carvalho M, Santos A, et al. Frailty syndrome: Visceral adipose tissue and frailty in patients with symptomatic severe aortic stenosis. J Nutr Health Aging. 2017;21(1):120-8. https://doi.org/10.1007/s12603-016-0795-x

Mullie L, Obrand A, Bendayan M, Trnkus A, Ouimet MC, Moss E, et al. Phase angle as a biomarker for frailty and postoperative mortality: the BICS study. J Am Heart Assoc. 2018;7(17):e8721. https://doi.org/10.1161/JAHA.118.008721

Bosy-Westphal A, Danielzik S, Dörhöfer RP, Later W, Wiese S, Müller MJ. Phase angle from bioelectrical impedance analysis: population reference values by age, sex, and body mass index. JPEN J Parenter Enteral Nutr. 2006;30(4):309-16. https://doi.org/10.1177/0148607106030004309

Del Giorno R, Quarenghi M, Stefanelli K, Rigamonti A, Stanglini C, De Vecchi V, et al. Phase angle is associated with length of hospital stay, readmissions, mortality, and falls in patients hospitalized in internal-medicine wards: A retrospective cohort study. Nutrition. 2021;85:111068. https://doi.org/10.1016/j.nut.2020.111068

Denneman N, Hessels L, Broens B, Gjaltema J, Stapel SN, Stohlmann J, et al. Fluid balance and phase angle as assessed by bioelectrical impedance analysis in critically ill patients: a multicenter prospective cohort study. Eur J Clin Nutr. 2020;74(10):1410-19. https://doi.org/10.1038/s41430-020-0622-7

Cândido ACO, Luquetti SCPD. Risco nutricional em pacientes críticos utilizando o método Nutric Score Risk. Nutr Clin Diet Hosp. 2019;39(2):19-25. https://doi.org/10.12873/392cándido

Utami RCB, Zulkifli Z, Zainal R, Saleh MI. Korelasi Modified Nutric Score dengan Mortalitas 28 Hari Pasien Sepsis di Unit Perawatan Intensif RSUP Dr. Mohammad Hoesin Palembang. J Anest Perioperatif. 2020;8(1). https://doi.org/10.15851/jap.v8n1.1980

Kalaiselvan MS, Renuka MK, Arunkumar AS. Use of Nutrition Risk in Critically ill (NUTRIC) Score to Assess Nutritional Risk in Mechanically Ventilated Patients: A Prospective Observational Study. Indian J Crit Care Med. 2017;21(5):253-6. https://doi.org/10.4103/ijccm.IJCCM_24_17

Reis AM, Fructhenicht AV, Moreira LF. Uso do escore NUTRIC pelo mundo: uma revisão sistemática. Rev Bras Ter Intensiva. 2019;31(3):379-85. https://doi.org/10.5935/0103-507X.20190061

Eslamian G, Ardehali SH, Shariatpanahi ZV. Association of intestinal permeability with a NUTRIC score in critically ill patients. Nutrition. 2019;63-64:1-8. https://doi.org/10.1016/j.nut.2019.01.010

Al Kalaldeh MT. Quantifying the risk of malnutrition in the critically ill using nutric score and phase angle. Clin Nutr. 2018;37(Suppl 1):s55. https://doi.org/10.1016/j.clnu.2018.06.1239