Presence of symptoms after COVID-19 infection may explain the onset of female urinary incontinence: a cross-sectional study
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Abstract
Introduction: Coronavirus 2019 (COVID-19) is a multisystem disease that may affect lower urinary tract function. Objective: To determine if symptoms after COVID-19 infection may explain the onset of urinary incontinence (UI) in female survivors; to investigate the impacts of symptoms on the quality of life of incontinent women. Methods: Cross-sectional study carried out online which included Brazilian women aged 18 years or older who developed UI during or after the COVID-19 infection, and were infected during the last three-months before data collection. Participants answered a semi structured questionnaire with sociodemographic and clinical questions; and validated questionnaires to assess UI symptoms (3-Incontinence Questionnaire; and International Consultation on Incontinence Questionnaire – Short Form). Multiple linear and binary logistic regression analysis were performed. Results: 879 women were included. Symptoms after COVID-19 infection had a statistically significant impact on stress UI, urgency UI, and mixed UI, predicting adequately 75.7%, 84.6%, and 73.4% of the cases, respectively. Muscle pain impacted the quality of life of women with UI, explaining 6.3% of UI. Other symptoms (i.e., diarrhea, tingling, and difficulty in breathing) explained 5.2% of of the impact on quality of life in women with UI. The resence of a cough for more than three weeks impacted the quality of life of women with UI, explaining 2.7% of the outcome. Conclusion: Post-COVID-19 symptoms can explained the onset of UI. The presence of cough lasting more than 3 weeks impact the women’s quality of life.
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Simpson R, Robinson L. Rehabilitation After Critical Illness in People With COVID-19 Infection. Am J Phys Med Rehabil. 2020;99(6):470-4. https://doi.org/10.1097/PHM.0000000000001443
World Health Organization (WHO). Coronavirus disease (COVID-19) pandemic. Available from: https://www.who.int/europe/emergencies/situations/covid-19
Halpin SJ, McIvor C, Whyatt G, Adams A, Harvey O, McLean L, et al. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation. J Med Virol. 2021;93(2):1013-22. https://doi.org/10.1002/jmv.26368
Siracusa C, Gray A. Pelvic Floor Considerations in COVID-19. J Womens Health Phys Therap. 2020;44(4):144-51. https://doi.org/10.1097/JWH.0000000000000180
D’Ancona C, Haylen B, Oelke M, Abranches-Monteiro L, Arnold E, Goldman H, et al. The International Continence Society (ICS) report on the terminology for adult male lower urinary tract and pelvic floor symptoms and dysfunction. Neurourol Urodyn. 2019;38(2):433-77. https://doi.org/10.1002/nau.23897
Deffieux X, Hubeaux K, Porcher R, Ismael S, Raibaut P, Amarenco G. Abnormal pelvic response to cough in women with stress urinary incontinence. Neurourol Urodyn. 2008;27(4):291-6. https://doi.org/10.1002/nau.20506
Deffieux X, Hubeaux K, Porcher R, Ismael S, Raibaut P, Amarenco G. Decrease in urethral pressure following repeated cough efforts: a new concept for pathophysiology of stress urinary incontinence. Int J Urol. 2007;14(11):1019-24. https://doi.org/10.1111/j.1442-2042.2007.01887.x
Pizzol D, Demurtas J, Celotto S, Maggi S, Smith L, Angiolelli G, et al. Urinary incontinence and quality of life: a systematic review and meta-analysis. Aging Clin Exp Res. 2021;33(1):25-35. https://doi.org/10.1007/s40520-020-01712-y
Gomes CM, Favorito LA, Henriques JVT, Canalini AF, Anzolch KMJ, Fernandes RC, et al. Impact of COVID-19 on clinical practice, income, health and lifestyle behavior of Brazilian urologists. Int Braz J Urol. 2020;46(6):1042-71. https://doi.org/10.1590/S1677-5538.IBJU.2020.99.15
von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for reporting observational studies. Int J Surg. 2014;12(12):1495-9. https://doi.org/10.1016/J.IJSU.2014.07.013
Centers for Disease Control and Prevention (CDC). Post-COVID Conditions: information for Healthcare providers. Available from: https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/post-covid-conditions.html
II Diretrizes Brasileiras no Manejo na Tosse Crônica. J Bras Pneumol. 2006;32(suppl 6):403S-46. https://doi.org/10.1590/S1806-37132006001000002
Alem MER, Silva JB, Beleza ACS, Chaves TC, Driusso P. Cross-cultural adaptation and measurement property analysis of the Brazilian Portuguese version of the Three Incontinence Questionnaire. Int Urogynecol J. 2022;33(11):3053-60. https://doi.org/10.1007/s00192-021-05036-x
Tamanini JTN, Dambros M, D’Ancona CAL, Palma PCR, Rodrigues Netto Jr N. Validação para o português do “International Consultation on Incontinence Questionnaire - Short Form” (ICIQ-SF). Rev Saude Publica. 2004;38(3):438-44. https://doi.org/10.1590/S0034-89102004000300015
Brilhante MMS, Marinho MFD, Magalhães AG, Correia GN. Impact of the SARS-CoV-2 pandemic on urinary incontinence and quality of life of nulliparous women. Rev Gaucha Enferm. 2022;43:e20200479. https://doi.org/10.1590/1983-1447.2022.20200479.en
Ferrari A, Corazza I, Mannella P, Simoncini T, Bonciani M. Influence of COVID‐19 pandemic on self‐reported urinary incontinence during pregnancy and postpartum: A prospective study. Int J Gynecol Obstet. 2023;160(1):187-94. https://doi.org/10.1002/ijgo.14522
Yildirim M, Minobes-Molina E, Oliveira VR, Coll-Planas L, Moreno-Martin P, Rierola-Fochs S, et al. How did the COVID-19 pandemic affect urinary incontinence and its management in the nursing homes? A descriptive phenomenological study. Neurourol Urodyn. 2023;42(2):409-18. https://doi.org/10.1002/nau.25120
Wang W, Xu Y, Gao R, Lu R, Han K, Wu G, et al. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. 2020;323(18):1843-4. https://doi.org/10.1001/jama.2020.3786
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. https://doi.org/10.1001/jama.2020.1585
Tannenbaum C, Gray M, Hoffstetter S, Cardozo L. Comorbidities associated with bladder dysfunction. Int J Clin Pract. 2013;67(2):105-13. https://doi.org/10.1111/ijcp.12085
Deguchi K, Ikeda K, Goto R, Tsukaguchi M, Urai Y, Kurokohchi K, et al. The close relationship between life-threatening breathing disorders and urine storage dysfunction in multiple system atrophy. J Neurol. 2010;257(8):1287-92. https://doi.org/10.1007/s00415-010-5508-5
Mumm JN, Osterman A, Ruzicka M, Stihl C, Vilsmaier T, Munker D, et al. Urinary Frequency as a Possibly Overlooked Symptom in COVID-19 Patients: Does SARS-CoV-2 Cause Viral Cystitis? Eur Urol. 2020;78(4):624-8. https://doi.org/10.1016/j.eururo.2020.05.013
Lamb LE, Dhar N, Timar R, Wills M, Dhar S, Chancellor MB. COVID-19 inflammation results in urine cytokine elevation and causes COVID-19 associated cystitis (CAC). Med Hypotheses. 2020;145:110375. https://doi.org/10.1016/j.mehy.2020.110375
Erekson EA, Ciarleglio MM, Hanissian PD, Strohbehn K, Bynum JPW, Fried TR. Functional disability and compromised mobility among older women with urinary incontinence. Female Pelvic Med Reconstr Surg. 2015;21(3):170-5. https://doi.org/10.1097/SPV.0000000000000136
Parker-Autry C, Houston DK, Rushing J, Richter HE, Subak L, Kanaya AM, et al. Characterizing the functional decline of older women with incident urinary incontinence. Obstet Gynecol. 2017;130(5):1025-32. https://doi.org/10.1097/AOG.0000000000002322
Christianson JA, Liang R, Ustinova EE, Davis BM, Fraser MO, Pezzone MA. Convergence of Bladder and Colon Sensory Innervation Occurs at the Primary Afferent Level. Pain. 2007;128(3):235-43. https://doi.org/10.1016/j.pain.2006.09.023
Matsumoto S, Hashizume K, Wada N, Hori J, Tamaki G, Kita M, et al. Relationship between overactive bladder and irritable bowel syndrome: A large-scale internet survey in Japan using the overactive bladder symptom score and Rome III criteria. BJU Int. 2013;111(4):647-52. https://doi.org/10.1111/j.1464-410X.2012.11591.x
Frawley H, Shelly B, Morin M, Bernard S, Bø K, Digesu GA, et al. An International Continence Society (ICS) report on the terminology for pelvic floor muscle assessment. Neurourol Urodyn. 2021;40(5):1217-60. https://doi.org/10.1002/nau.24658
Deng DY. Urinary incontinence in women. Med Clin North Am. 2011;95(1):101-9. https://doi.org/10.1016/j.mcna.2010.08.022
World Health Organization (WHO). The World Health Organization Quality of Life (WHOQOL). Available from: https://www.who.int/publications/i/item/WHO-HIS-HSI-Rev.2012.03
Krhut J, Gärtner M, Mokris J, Horcicka L, Svabik K, Zachoval R, et al. Effect of severity of urinary incontinence on quality of life in women. Neurourol Urodyn. 2018;37(6):1925-30. https://doi.org/10.1002/NAU.23568