Correlation between Nutritional Parameters, Peripheral muscle strength, and functional capacity of Children and Adolescents with Cystic Fibrosis
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Abstract
Introduction: Cystic fibrosis (CF) is an autosomal recessive genetic disorder caused by different mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, responsible for chloride ion transport across apical membranes of epithelial cells in tissues and bicarbonate secretion. Objective: To investigate the correlation of anthropometric parameters of nutritional status, lung function, peripheral strength, and functional capacity in children and adolescents diagnosed with CF. Methods: A cross-sectional study was carried out with 18 children, adolescents with CF aged between 6 and 15 years old. Anthropometric, body composition, bioimpedance, lung function, and peripheral muscle strength and functional capacity data were collected. Results: The pulmonary function assessment indexes FEV1 and FVC presented a statistically significant correlation with the nutritional status parameters - corrected lean mass (CLM), mid-upper arm circumference (MUAC), mid-arm muscle circumference (MAMC), with manual dynamometry. Concerning the parameters of the peripheral muscle strength and functional capacity, both the six-minute walk test and manual dynamometry showed a positive correlation with the height/age, CLM, MUAC, and MAMC index. Conclusion: Given the correlation between nutritional parameters that reflect muscle mass with lung function, peripheral muscle strength, and functional capacity, the incorporation of these anthropometric measures in the clinical routine could allow a better assessment of the muscular component and the health status of these patients.
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