Concentrações de IL-6, TNF-α e MCP-1 em crianças com excesso de massa corporal

Juliano Magalhães Guedes, José Botempo Mamêde Neto, Jéssica de Fátima Xavier dos Santos, Rafael Frata Cândido, Alynne Chrystian Ribeiro Andaki, Edmar Lacerda Mendes

Resumo


O objetivo desta revisão sistemática foi verificar a relação das concentrações de IL-6, TNF-α e MCP-1 em crianças com excesso de massa corporal. As bases de dados investigadas PUBMED, SciELO, LILACS e Periódico Capes foram consultadas retrospectivamente para os últimos seis anos (2009 a 2014) utilizando combinações de palavras chaves como inflamação, IL-6, TNF-α, MCP-1 combinadas com crianças e escolares. Foram analisados 21 artigos. Foi encontrado associação entre sobrepeso/obesidade com IL-6, TNF-α e MCP-1 em 73,3% (11/15), 80% (12/15) e 60% (3/5) dos estudos que analisaram tais marcadores, respectivamente. Crianças com excesso de massa corporal possuem concentrações elevadas de IL-6, TNF-α e MCP-1 resultando em inflamação sistêmica crônica e aumentando o risco de desenvolvimento de outras doenças cardiovasculares. 


Palavras-chave


inflamação; obesidade; criança; saúde escolar

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Referências


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DOI: https://doi.org/10.7322/abcshs.v40i2.736

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