Concentrations of IL-6, TNF-α and MCP-1 in children with excess of body mass

Juliano Magalhães Guedes, José Botempo Mamêde Neto, Jéssica de Fátima Xavier dos Santos, Rafael Frata Cândido, Alynne Chrystian Ribeiro Andaki, Edmar Lacerda Mendes

Abstract


This systematic review aimed to verify the relationship of IL-6, TNF-α and MCP-1 concentrations in children with excess of body mass. The databases PUBMED, SciELO, LILACS and Periódicos Capes were consulted retrospectively for the last 6 years (2009 to 2014) using combined of keywords like inflammation, IL-6, TNF-α, MCP-1 combined with children and schoolers. A total of 21 articles were analyzed. We found an association between overweight/obesity with IL-6, TNF-α and MCP-1 in 73.3% (11/15), 80% (12/15) and 60% (3/5) in the studies that analyzed these markers, respectively. Children with excess of body mass have high concentrations of IL-6, TNF-α and MCP-1 resulting in chronic systemic inflammation and increasing the risk of developing other cardiovascular diseases.


Keywords


inflammation; obesity; child; school health

References


Ahuja B, Klassen AF, Satz R, Malhotra N, Tsangaris E, Ventresca M, et al. A review of patient-reported outcomes for children and adolescents with obesity. Qual Life Res. 2014;23(3):759-70. http://dx.doi.org/10.1007/s11136-013-0459-9

World Health Organization (WHO). Childhood overweight and obesity. Resource Document. Geneva. 2013. Disponível em: http://www.who.int/dietphysicalactivity/childhood/en/. Acesso em: 19 maio 2015.

Duncan BB, Chor D, Aquino EML, Bensenor IM, Mill JG, Schmidt MI, et al. Doenças crônicas não transmissíveis no Brasil: prioridade para enfrentamento e investigação. Rev Saúde Pública. 2012;46(supl. 1):126-34. http://dx.doi.org/10.1590/S0034-89102012000700017

Thompson DR, Obarzanek E, Franko DL, Barton BA, Morrison J, Biro FM, et al. Childhood overweight and cardiovascular disease risk factors: the National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatrics. 2007;150(1):18-25. http://dx.doi.org/10.1016/j.jpeds.2006.09.039

Sinaiko AR. Síndrome metabólica em crianças. J Pediatr. 2012;88(4):286-8. http://dx.doi.org/10.2223/JPED.2214

Volp ACP, Alfenas RCG, Costa NMB, Minin VPR, Stringueta PC, Bressan J. Capacidade dos biomarcadores inflamatórios em predizer a síndrome metabólica. Arq Bras Endocrinol Metab. 2008;52(3):537-49. http://dx.doi.org/10.1590/S0004-27302008000300015

Geraldo JM, Alfenas RCG. Papel da dieta na prevenção e no controle da inflamação crônica - evidências atuais. Arq Bras Endocrinol Metab. 2008;52(6):951-67. http://dx.doi.org/10.1590/S0004-27302008000600006

Chizzolini C, Dayer JM, Miossec P. Cytokines in chronic rheumatic diseases: is everything lack of homeostatic balance? Arthritis Res Ther. 2009;11(5):246.

Panee J. Monocyte Chemoattractant Protein 1 (MCP-1) in obesity and diabetes. Cytokine. 2012;60(1):1-12. http://dx.doi.org/10.1016/j.cyto.2012.06.018

Eder K, Baffy N, Falus A, Fulop AK. The major inflammatory mediator interleukin-6 and obesity. Inflamm Res. 2009;58(11):727-36. http://dx.doi.org/10.1007/s00011-009-0060-4

Tilg H, Moschen AR. Inflammatory mechanisms in the regulation of insulin resistance. Mol Med. 2008;14(3-4):222-31. http://dx.doi.org/10.2119/2007-00119.Tilg

Tam CS, Garnett SP, Cowell CT, Heilbronn LK, Lee JW, Wong M, et al. IL-6, IL-8 and IL-10 levels in healthy weight and overweight children. Horm Res Paediatr. 2010;73(2):128-34. http://dx.doi.org/10.1159/000277632

Maffeis C, Silvagni D, Bonadonna R, Grezzani A, Banzato C, Tato L. Fat cell size, insulin sensitivity, and inflammation in obese children. J Pediatr. 2007;151(6):647-52. http://dx.doi.org/10.1016/j.jpeds.2007.04.053

Dixon D, Meng H, Goldberg R, Schneiderman N, Delamater A. Stress and body mass index each contributes independently to tumor necrosis factor-alpha production in prepubescent Latino children. J Pediatr Nurs. 2009;24(5):378-88. http://dx.doi.org/10.1016/j.pedn.2008.02.034

Kim J, Bhattacharjee R, Kheirandish-Gozal L, Khalyfa A, Sans Capdevila O, Tauman R, et al. Insulin sensitivity, serum lipids, and systemic inflammatory markers in school-aged obese and nonobese children. Int J Pediatr. 2010;2010:846098. http://dx.doi.org/10.1155/2010/846098

Breslin WL, Johnston CA, Strohacker K, Carpenter KC, Davidson TR, Moreno JP, et al. Obese Mexican American children have elevated MCP-1, TNF-alpha, monocyte concentration, and dyslipidemia. Pediatr. 2012;129(5):e1180-6. http://dx.doi.org/10.1542/peds.2011-2477

Codoner-Franch P, Tavarez-Alonso S, Simo-Jorda R, Laporta-Martin P, Carratala-Calvo A, Alonso-Iglesias E. Vitamin D status is linked to biomarkers of oxidative stress, inflammation, and endothelial activation in obese children. J Pediatr. 2012;161(5):848-54. http://dx.doi.org/10.1016/j.jpeds.2012.04.046

Tsaoussoglou M, Bixler EO, Calhoun S, Chrousos GP, Sauder K, Vgontzas AN. Sleep-disordered breathing in obese children is associated with prevalent excessive daytime sleepiness, inflammation, and metabolic abnormalities. J Clin Endocrinol Metab. 2010;95(1):143-50. http://dx.doi.org/10.1210/jc.2009-0435

Elshorbagy AK, Valdivia-Garcia M, Refsum H, Butte N. The association of cysteine with obesity, inflammatory cytokines and insulin resistance in Hispanic children and adolescents. PloS One. 2012;7(9):e44166. http://dx.doi.org/10.1371/journal.pone.0044166

Alvarez JA, Higgins PB, Oster RA, Fernandez JR, Darnell BE, Gower BA. Fasting and postprandial markers of inflammation in lean and overweight children. Am J Clin Nutr. 2009;89(4):1138-44. http://dx.doi.org/10.3945/ajcn.2008.26926

Bugge A, El-Naaman Hermansen B, Froberg K, McMurray RG, Andersen LB. Longitudinal Relationship between inflammatory markers in adolescents and childhood fatness, fitness and physical activity: 1351: board. Med Sci Sports Exerc. 2011;43(5):273-4. http://dx.doi.org/10.1249/01.MSS.0000400751.12462.bd

Chirico V, Cannavo S, Lacquaniti A, Salpietro V, Mandolfino M, Romeo PD, et al. Prolactin in obese children: a bridge between inflammation and metabolic-endocrine dysfunction. Clin Endocrinol. 2013;79(4):537-44. http://dx.doi.org/10.1111/cen.12183

Andersen LB, Muller K, Eiberg S, Froberg K, Andersen JF, Bugge A, et al. Cytokines and clustered cardiovascular risk factors in children. Metabolism. 2010;59(4):561-6. http://dx.doi.org/10.1016/j.metabol.2009.08.019

Garanty-Bogacka B, Syrenicz M, Goral J, Krupa B, Syrenicz J, Walczak M, et al. Changes in inflammatory biomarkers in obese children. Endocrinol Pol. 2011;62 (6):499–505.

Ben Ounis O, Elloumi M, Zouhal H, Makni E, Denguezli M, Amri M, et al. Effect of individualized exercise training combined with diet restriction on inflammatory markers and IGF-1/IGFBP-3 in obese children. Ann Nutr Metab. 2010;56(4):260-6. http://dx.doi.org/10.1159/000275888

Codoner-Franch P, Tavarez-Alonso S, Murria-Estal R, Megias-Vericat J, Tortajada-Girbes M, Alonso-Iglesias E. Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation. Atherosclerosis. 2011;215(2):475-80. http://dx.doi.org/10.1016/j.atherosclerosis.2010.12.035

Metzig AM, Schwarzenberg SJ, Fox CK, Deering MM, Nathan BM, Kelly AS. Postprandial endothelial function, inflammation, and oxidative stress in obese children and adolescents. Obesity (Silver Spring). 2011;19(6):1279-83. http://dx.doi.org/10.1038/oby.2010.318

Roth CL, Kratz M, Ralston MM, Reinehr T. Changes in adipose-derived inflammatory cytokines and chemokines after successful lifestyle intervention in obese children. Metabolism. 2011;60(4):445-52. http://dx.doi.org/10.1016/j.metabol.2010.03.023

Pyrzak B, Wisniewska A, Majcher A, Popko K, Wasik M, Demkow U. Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese children. Eur J Med Res. 2009;14(supl. 4):196-200.

Giordano P, Del Vecchio GC, Cecinati V, Delvecchio M, Altomare M, De Palma F, et al. Metabolic, inflammatory, endothelial and haemostatic markers in a group of Italian obese children and adolescents. Eur J Pediatr. 2011;170(7):845-50. http://dx.doi.org/10.1007/s00431-010-1356-7

Jermendy A, Korner A, Kovacs M, Kaszas E, Balazsovics J, Szocs A, et al. Association between toll-like receptor polymorphisms and serum levels of tumor necrosis factor-alpha and its soluble receptors in obese children. Med Sci Monit. 2010;16(4):CR180-5.

Pyrzak B, Wisniewska A, Popko K, Demkow U, Kucharska AM. Association between anthropometric measures of obesity, metabolic disturbances and polymorphism G-308A of the tumor necrosis factor-alpha gene in children. Eur J Med Res. 2010;15(Suppl 2):141-6.

Wasilewska A, Tenderenda E, Taranta-Janusz K, Tobolczyk J, Stypulkowska J. Markers of systemic inflammation in children with hyperuricemia. Acta Paediatr. 2012;101(5):497-500. http://dx.doi.org/10.1111/j.1651-2227.2011.02582.x

Bugge A, El-Naaman B, McMurray RG, Froberg K, Nielsen CH, Muller K, et al. Inflammatory markers and clustered cardiovascular disease risk factors in Danish adolescents. Horm Res Paediatr. 2012;78(5-6):288-96. http://dx.doi.org/10.1159/000345546

Singh T, Newman AB. Inflammatory markers in population studies of aging. Ageing Res Rev. 2011;10(3):319-29. http://dx.doi.org/10.1016/j.arr.2010.11.002

Wu JT, Wu LL. Linking inflammation and atherogenesis: Soluble markers identified for the detection of risk factors and for early risk assessment. Clin Chim Acta. 2006;366(1-2):74-80. http://dx.doi.org/10.1016/j.cca.2005.10.016

Gomes F, Telo DF, Souza HP, Nicolau JC, Halpern A, Serrano Jr CV. Obesidade e doença arterial coronariana: papel da inflamação vascular. Arq Bras Cardiol. 2010;94(2):273-9. http://dx.doi.org/10.1590/S0066-782X2010000200021

Esteve E, Ricart W, Fernandez-Real JM. Dyslipidemia and inflammation: an evolutionary conserved mechanism. Clin Nutr. 2005;24(1):16-31. http://dx.doi.org/10.1016/j.clnu.2004.08.004




DOI: https://doi.org/10.7322/abcshs.v40i2.736

Refbacks

  • There are currently no refbacks.


Copyright (c) 2015 Guedes et al.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.