Impact of gestational diabetes mellitus in human placental mass

Main Article Content

Cleiton Jonei Reginatto
Vinicius Mazzetti Subtil
Lisandra Vieira Rodrigues
Vitor Engrácia Valenti
Luiz Carlos de Abreu
Rayana Loch Gomes
Marcio Petenusso

Abstract

Introduction: Gestational diabetes mellitus (GDM) is a pathological alteration of maternal energy metabolism unleashed by the pregnant woman’s inability to produce sufficient amounts of insulin to compensate for glucose intolerance triggered by the action of placental lactogenic hormone (HPL). Given that plasma levels of HPL are proportional to the placenta mass and that they are close to the maximum period in which the placenta acquires its larger size and that hyperglycemia is manifested in pregnant women with GDM, it is possible to infer that there might be correlation between the placental mass and this disease. Objective: To evaluate whether there is correlation between GDM and placental mass. Methods: Descriptive, cross-sectional and quantitative approach survey, which was conducted in a public hospital in Santa Catarina, Brazil. The survey included 20 pregnant women, 10 with and 10 without GDM, who agreed to participate in the study. Results: The average of placenta masses of the Control Group was 505.63±12.18 g, while of the GDM group it was 561,00 ±14.25 g. Conclusion: This study suggests that placental mass of pregnant women with GDM is significantly greater than the mass placenta of healthy pregnant women.

Downloads

Download data is not yet available.

Article Details

How to Cite
Reginatto, C. J., Subtil, V. M., Rodrigues, L. V., Valenti, V. E., Abreu, L. C. de, Gomes, R. L., & Petenusso, M. (2016). Impact of gestational diabetes mellitus in human placental mass. ABCS Health Sciences, 41(1). https://doi.org/10.7322/abcshs.v41i1.840
Section
Original Articles

References

1. Porth CM. Fisiopatologia. 6a ed. Rio de Janeiro: Guanabara Koogan; 2004.

2. Freitas F. Rotinas em Obstetrícia. 6ª ed. Porto Alegre: Artmed; 2011.

3. Zugaib M. Zugaib Obstetrícia. 2a ed. Porto Alegre: Manole; 2012.

4. International Association of Diabetes and Pregnancy Study Groups Consensus Panel. International Association of Diabetes and Pregnancy Study Groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33(3):676-82. http://dx.doi.org/10.2337/dc09-1848

5. American Diabetes Association. Standards of medical care in diabetes 2011. Diabetes Care. 2011;34(Suppl 1):S11-61. http://dx.doi.org/10.2337/dc11-S011

6. Sociedade Brasileira de Diabetes. Diretrizes da Sociedade Brasileira de Diabetes 2014-2015. 3 ed. São Paulo: AC Farmacêutica; 2014.

7. Sociedade Brasileira de Endocrinologia e Metabologia. Diabetes mellitus gestacional. Rev Assoc Med Bras. 2008;54(6):477-80. http://dx.doi.org/10.1590/S0104-42302008000600006

8. Lima DA, Brasileiro AA, Rosa LP. Riscos e consequências do diabetes gestacional: uma revisão bibliográfica. Estudos. 2012;39(4):561-7.

9. Rezende J. Obstetrícia. 10ª ed. Rio de Janeiro: Guanabara Koogan; 2005.

10. Menicatti M, Fregonesi CEPT. Diabetes gestacional: aspectos fisiopatológicos e tratamento. Arq Ciências Saúde Unipar. 2006;10(2):105-11.

11. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Spong CY. Obstetrícia de Williams. 23ª ed. Rio de Janeiro: Mc Graw Hill; 2012.

12. Boime I, McWilliams D, Szczesna E, Camel M. Synthesis of human placental lactogen messenger RNA as a function of gestation. J Biol Chem. 1976;251(3):820-5.

13. McWilliams D, Callaham RC, Boime I. Human placental lactogen messenger RNA and its structural genes during pregnancy: quantitation with a complementary DNA. Proc Natl Acad Sci USA. 1977;74(3):1024-7.

14. Guariento A, Mamede JAV. Medicina materno-fetal. São Paulo: Atheneu; 2001.

15. Neme B. Obstetríca básica. 2a ed. São Paulo: Sarvier; 2000.

16. Strøm-Roum EM, Haavaldsen C, Tanbo TG, Eskild A. Placental weight relative to birthweight in pregnancies with maternal diabetes mellitus. Acta Obstet Gynecol Scand. 2013;92(7):783-9. http://dx.doi.org/10.1111/aogs.12104

17. Persson B, Hanson U, Marcus C. Gestational diabetes mellitus and paradoxical fetal macrossomia: a case report. Early Hum Dev. 1995;41(3):203-13.

18. Winick M. Cellular growth in human placent. III. Intrauterine growth failure. J Pediatr. 1967;71(3):390-5.

19. Del Nero U, Rudge MV, Novo NF, Calderon IM, Brasil MA. Metodologia para estudo do volume e densidade absoluta da placenta humana de termo. Rev Bras Ginecol Obstet. 2002;24(10):212-6. http://dx.doi.org/10.1590/S0100-72032002001000006

20. Pimenta EJ. Estimativa do volume placentário e da vascularização placentária por ultrassonografia tridimensional em gestações com síndromes hipertensivas. Dissertação (Mestrado) – Faculdade de Medicina da Universidade de São Paulo. São Paulo: 2013.