Neurological screening of preterm infants with peri- and intra-ventricular hemorrhage: observation transversal study

Main Article Content

Andréa Vancetto Maglione
Marina Ortega Golin
Roseli Oselka Saccardo Sarni

Abstract

Introduction: Preterm infants with less than 27 weeks of gestacional age present vulnerability for development of periand intraventricular hemorrhage (PIVH). This can affect the myelinization and organization of cerebral cortex, leading to possible developmental impairment. Objective: To evaluate the neurological behavior of preterm infants affected by PIVH with and without sepsis according to the Dubowitz Method summary, to delimit the presence of deviant items of the evaluation and to compare with the results of the control group (without PIVH). Methods: This is a cross-sectional study. The preterm infants were divided in three groups, two study groups (PIVH and PIVH + sepsis), and one control group. The summary version of the Dubowitz Method was used as a neurological screening for the risk in preterm infants. The analysis was performed according to scores with deviation in these items and compared to the expected normal score. Data obtained were compared using the summary score and the full version of the test. Results: The frequency of abnormal scores was: 40% in the group with PIVH + sepsis, 10% in the group only with PIVH, 15% in the control group. Conclusion: The PIVH does not seem to be a significant factor for the presence of items with deviation in the summary version of Dubowitz Method. The presence of PIVH in more severe stages was associated with the presence of sepsis. The preterm infants with PIVH with sepsis obtained worse neurological performance in the test.

Downloads

Download data is not yet available.

Article Details

How to Cite
Maglione, A. V., Golin, M. O., & Sarni, R. O. S. (2018). Neurological screening of preterm infants with peri- and intra-ventricular hemorrhage: observation transversal study. ABCS Health Sciences, 43(1). https://doi.org/10.7322/abcshs.v43i1.1162
Section
Original Articles

References

Rugolo LMSS. Growth and developmental outcomes of the extremely preterm infant. J Pediatr. 2005; 81(1): 101-110. http://dx.doi.org/10.1590/S0080-62342009000200030

Airoldi MJ, Silva SBC, Souza RCT. Avaliação de recém nascidos pré-termo com hemorragia peri-intraventricular e/ou leucomalácia periventricular. Rev Neurociênc. 2009;17(1):24-9.

Marba STM, Caldas JPS, Vinagre LEF, Pessoto MA. Incidência de hemorragia peri-intraventricular em recém-nascidos de muito baixo peso: análise de 15 anos. J Pediatr. 2011;87(6):505-11. http://dx.doi.org/10.1590/S0021-75572011000600008

Payne AH, Hintz SR, Hibbs AM, Walsh MC, Vohr BR, Bann CM, et al. Neurodevelopmental outcomes of extremely low-gestational-age neonates with low-grade periventricular-intraventricular hemorrhage. Jama Pediatr. 2013;167(5):451-9. http://dx.doi.org/10.1001/jamapediatrics.2013.866

Linder N, Haskin O, Levit O, Klinger G, Prince T, Naor N, Turner P, Karmazyn B, Sirota L. Risk factors for intraventricular hemorrhage in very low birth weight premature infants: a retrospective case-control study. Pediatrics. 2003;111(5):e590-e595.https://doi.org/10.1542/peds.111.5.e590

Cunha M, Bettencourt A, Almeida A, Mimoso G, Soares P, Tomé T. O recém nascido de extremo baixo peso. Estado aos 2-3 anos. Resultados do Registo Nacional de Muito Baixo Peso de 2005 e 2006. Acta Pediatr Port. 2013;44(1):1-8.

Kutuk MS, Yikilmaz A, Ozgun MT, Dolanbay M, Canpolat M, Uludag S, et al. Prenatal diagnosis and postnatal outcome of fetal intracranial hemorrhage. Childs Nerv Syst. 2014;30(3):411-8. http://dx.doi.org/10.1007/s00381-013-2243-0

Wusthoff CJ. How to use: the neonatal neurological examination. Arch Dis Child Educ Pract Ed. 2013;98(4):148-53.http://dx.doi.org/10.1136/archdischild-2013-303640

Pedroso FS, Rotta NT. Neurological examination in the healthy term newborn. Arq Neuropsiquiatr. 2003;61(2A):165-9.http://dx.doi.org/10.1590/S0004-282X2003000200001

Romeo DM, Ricci D, van Haastert IC, Vries LS, Haataja L, Brogna C, et al. neurologic assessment tool for screening preterm infants at term age. J Pediatr. 2012;161(6):1166-8.http://dx.doi.org/10.1016/j.jpeds.2012.07.037

Nascimento KK, Casagrande GMA, Golin MO. Avaliação neurológica de recém-nascidos a termo de baixo risco pelo Método Dubowitz. Arq Bras Ciênc Saúde. 2011;36(3):134-9.http://dx.doi.org/10.7322/abcs.v36i3.51

Golin MO, Souza FIS, Sarni ROS. Avaliação neurológica pelo método Dubowitz em recém-nascidos prematuros com idade corrigida de termo comparada a de nascidos a termo. Rev Paul Pediatr. 2009;27(4):402-9.http://dx.doi.org/10.1590/S0103-05822009000400009

Mercuri E, Ricci D, Pane M, Baranello G. The neurological examination of the newborn baby. Early Hum Dev. 2005;81912):947-56. http://dx.doi.org/10.1016/j.earlhumdev.2005.10.007

Fernandes LV, Goulart AL, Santos AMN, Barros MCM, Guerra CC, Kopelman BI. Avaliação do neurodesenvolvimento de prematuros de muito baixo peso ao nascer entre 18 e 24 meses de idade corrigida pelas escalas Bayley III. J Pediatr. 2012;88(6):471-8.http://dx.doi.org/10.1590/S0021-75572012000600005

Papile L-A, Burstein J, Burstein R, Kofller H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1500 g. J Pediatr. 1978; 92:529-34.https://doi.org/10.1016/s0022-3476(78)80282-0

Battaglia FC, Lubchenco LO. A practical classification of newborn infants by weight and gestational age. J Pediatr. 1967;71(2):159-63.http://dx.doi.org/10.1016/S0022-3476(67)80066-0

Capurro H, Konichezky S, Fonseca D, Caldeyro-Barcia R. A simplified method for diagnosis of gestational age in the newborn infant. J Pediatr. 1978;93(1):120-2. http://dx.doi.org/10.1016/S0022-3476(78)80621-0

Ballard JL, Khoury JC, Wedig K, Wang L, Eilers-Walsman BL, Lipp R. New Ballard Score, expanded to include extremely premature infants. J Pediatr. 1991;119(3):417-23. http://dx.doi.org/10.1016/S0022-3476(05)82056-6

Brazelton TB. Neonatal Behavioral Assessment Scale. Clin Dev Med. 1973;(50):48-54.

Dubowitz L, Mercuri E, Dubowitz V. An optimality score for the neurologic examination of the term newborn. J Pediatr. 1998;133(3):406-16. http://dx.doi.org/10.1016/S0022-3476(98)70279-3

Bouz P, Zouros A, Taha A, Sadanan V. Neonatal Intracerebral Hemorrhage: Mechanisms, Managements, and the Outcomes. Transl Stroke Res. 2012;3(Supl. 1):S6-9. http://dx.doi.org/10.1007/s12975-012-0180-y

Grinaboldi A, Hinnig P, Moura SPS, Golin MO. Avaliação neurológica de recém-nascidos pré-termo: correlação com fatores de risco neonatais. Rev Neurocienc. 2015;23(2):267-74.http://dx.doi.org/10.4181/RNC.2015.23.02.1017.8p

Silva AJ, Neves LAT, Frônio JS, Ribeiro LC. Factors related to motor developmental delay of newborns. J Hum Growth Dev. 2014;24(3):320-7.http://dx.doi.org/10.7322/jhgd.88970

Palmer P, Dubowitz LMS, Levene MI, Dubowitz V. Developmental and neurological progress of preterm infants with intraventricular haemorrhage and ventricular dilatation. Arch Dis Child. 1982;57(10):748-53.

Bejar R, Wozniak P, Allard M, Benirschke K, Vaucher Y, Coen R, et al. Antenatal origin of neurologic damage in newborn infants: I. Preterm infants. Am J Obstet Gynecol. 1988;159(2):357-63.http://dx.doi.org/10.1016/S0002-9378(88)80084-X

Hentges CR, Silveira RC, Procianoy RS, Carvalho CG, Filipouski GR, Fuentefria RN, et al. Association of late-onset neonatal sepsis with late neurodevelopment in the first two years of life of preterm infants with very low birth weight. J Pediatr. 2014;90(1):50-7.http://dx.doi.org/10.1016/j.jped.2013.10.002

Molteno C, Grosz P, Wallace P, Jones M. Neurological examination of the preterm and fullterm infant at risk for developmental disabilities using the Dubowitz Neurological Assessment. Early Hum Dev. 1995;41(3):167-76. http://dx.doi.org/10.1016/0378-3782(95)01621-9

Setänen S, Lahti K, Lehtonen L, Parkkola R, Maunu J, Saarinen K, et al. Neurological examination combined with brain MRI or cranial US improves prediction of neurological outcome in preterm infants. Early Hum Dev. 2014;90(12):851-6. http://dx.doi.org/10.1016/j.earlhumdev.2014.09.007